Understanding The NAChR Alpha2Beta2 Receptor (P16192)

Target Name: Neuronal acetylcholine receptor alpha2beta2 receptor

NCBI ID: P16192

Other Name(s): nAChR alpha2beta2 | alpha2beta2 Nicotinic receptor | Nicotinic alpha2beta2 receptor

Understanding The NAChR Alpha2Beta2 Receptor

Neuronal acetylcholine receptor alpha2beta2 (nAChR alpha2beta2) is a G protein-coupled receptor (GPCR) that is expressed in the central and peripheral nervous systems, including the brain. It is one of the most abundant GPCR in the nervous system and plays a crucial role in the function of the nervous system. Unfortunately, despite its importance, nAChR alpha2beta2 is also known as a drug target and has been the focus of extensive research in recent years.

The nAChR alpha2beta2 receptor is a GPCR that is characterized by four transmembrane domains: an extracellular domain, a transmembrane domain, an intracellular domain, and an optional C-terminal domain. The nAChR alpha2beta2 receptor is expressed in the brain and is involved in various physiological processes, including sensory perception, movement, and neurotransmitter release.

One of the key functions of the nAChR alpha2beta2 receptor is its role in neurotransmission. The nAChR alpha2beta2 receptor is involved in the regulation of neurotransmitter release and has been shown to play a role in the release of various neurotransmitters, including dopamine, serotonin, and GABA.

In addition to its role in neurotransmission, the nAChR alpha2beta2 receptor is also involved in the regulation of intracellular signaling pathways. It is a potent inhibitor of the protein kinase C (PKC) and has been shown to inhibit the activity of various signaling pathways, including the cAMP/Cas signaling pathway.

Despite its importance, the nAChR alpha2beta2 receptor is also a drug target. Several compounds have been shown to interact with the nAChR alpha2beta2 receptor and have been developed as potential drugs for various neurological disorders. For example, a compound called NAChR伪2尾2 antagonist (NAChaR) has been shown to block the effects of various neurotransmitters, including dopamine and GABA, and has been shown to be effective in treating symptoms of Alzheimer's disease.

In conclusion, the nAChR alpha2beta2 receptor is an important GPCR that is involved in various physiological processes in the nervous system. Its function as a neurotransmission regulator and its role as a drug target make it an attractive target for the development of new treatments for neurological disorders. Further research is needed to fully understand the role of the nAChR alpha2beta2 receptor and to develop effective treatments.

Protein Name: Neuronal Acetylcholine Receptor Alpha2beta2 Receptor

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